Sodium Hydroxide → 1-(4-(3-(Cyclopropylmethyl)ureido)benzoyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-2-carboxylic acid

Participants

Reaction Steps

Methyl 1-(4-(3-(cyclopropylmethyl)ureido)benzoyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-2-carboxylate (0.032 mmol, 0.02 g) and sodium hydroxide (0.032 mmol, 1.298 mg) were combined and heated to 80° C. in methanol (1 mL) for 6 hours in a reactivial. The reaction mixture was concentrated under reduced pressure. The resulting residue was passed down an SCX column to afford the title compound (16 mg). MS (ESI) m/z 603.2 [M+H]+

Provenance & Evidence