Water → HCID 59175838, compound

Participants

Reaction Steps

4-Nitrophenyl carbonochloridate (0.126 mmol, 0.02549 g) was added to a stirred solution of 2-(4-((4-(4-aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.126 mmol, 0.0629 g) in dichloromethane (1 mL). After 1 hour, cyclopropylethanamine (0.380 mmol, 0.027 g) was added and stirring was continued for 1 hour. Water (5 mL) was added and the organic layer was separated, washed with water (3×10 mL), dried over magnesium sulphate and concentrated under reduced pressure to give a yellow gum. Purification was achieved by preparative HPLC, giving after filtration through a silica carbonate column in methanol, the title compound as a pale gum (15.2 mg). MS (ESI) m/z 595.0 [M+H]+

Provenance & Evidence