Carbamic acid, 4-pyridinyl-, phenyl ester → HCID 59175854, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-((4-(4-Aminophenyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (0.231 mmol, 0.1 g) and phenyl pyridin-4-ylcarbamate (0.346 mmol, 0.074 g) were combined in dioxane (1 mL) in a Reactivial and heated to 100° C. for 2 days. The reaction mixture was concentrated at reduced pressure. The resulting residue was taken up in dichloromethane, washed with water, dried over sodium sulphate and concentrated at reduced pressure. The residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 6% methanol/dichloromethane) to afford the title compound (43 mg). MS (ESI) m/z 555.2 [M+H]+

Provenance & Evidence