Ethyl 4-isocyanatobenzoate → HCID 59175898, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-((4-(4-Aminophenyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.461 mmol, 200 mg) and ethyl 4-isocyanatobenzoate (0.554 mmol, 0.060 mL, 106 mg) were combined in dichloromethane and heated in a microwave at 100° C. for 10 minutes. The reaction mixture was concentrated under vacuum. The residue was purified by acidic preparative HPLC and SCX chromatography to afford the title compound (212.3 mg). MS (ESI) m/z 625.2 [M+H]+

Provenance & Evidence