反应详情

温度

65 °C

Methyl 4-(2-(cyclopropylmethylamino)-2-oxoethyl)benzoate (5.26 mmol, 1.3 g), and sodium hydroxide (5.26 mmol, 0.210 g) were combined in methanol (15 mL) and the reaction mixture was stirred and refluxed at 65° C. After 4 hours, an additional equivalent of sodium hydroxide (5.26 mmol, 0.210 g) was added and reaction mixture stirred and refluxed at 65° C. overnight. The reaction mixture was concentrated under vacuum to afford the title compound (1.7 g). MS (ESI) m/z 234.0 [M+H]+

1. customreaction mixture
2. stirringstirred
3. temperaturerefluxed at 65° C. overnight
4. concentrationThe reaction mixture was concentrated under vacuum