Cyanogen Bromide → HCID 45101106, compound

HRID 1807905Notes

Reaction equation

HRID 1807905 reaction equation
[NH2:1][C@@H:2]([CH2:5][O:6][CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8])[CH2:3][OH:4].[N:15]#[C:16]Br>>[C:9]1([CH:7]([O:6][CH2:5][C@H:2]2[CH2:3][O:4][C:16]([NH2:15])=[N:1]2)[CH3:8])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 67228863HCID 67228863, compound

Product 1

HCID 45101106HCID 45101106, compound

Procedure

In analogy to example 1d (R)-2-amino-3-(1-phenyl-ethoxy)-propan-1-ol was reacted with cyanogen bromide to give (4S)-4-(1-phenyl-ethoxymethyl)-4,5-dihydro-oxazol-2-ylamine. Light yellow oil. MS (ISP): 221.3 ([M+H]+)).

Sources & evidence

ORD record
ord-6a60ac6b563041c48beaac0486f0e847
Source dataset
uspto-grants-2013_01
Patent number
US08357712B2

Reaction notes

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