HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → (S)-4-[2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyl]-4,5-dihydro-oxazol-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | (S)-2-amino-4-(5-trifluoromethyl-pyridin-2-yloxy)-butan-1-ol | HCID 59173196 | — |
| Product | (S)-4-[2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyl]-4,5-dihydro-oxazol-2-ylamine | HCID 59173170 | — |
Reaction Steps
In analogy to example 1d (S)-2-amino-4-(5-trifluoromethyl-pyridin-2-yloxy)-butan-1-ol was reacted with cyanogen bromide to give (S)-4-[2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyl]-4,5-dihydro-oxazol-2-ylamine. White solid. MS (ISP): 276.2 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08357712B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-42c5adeead934c0192e340f42aabf280 |
| Source note | uspto-grants-2013_01 |