反应详情

温度

100 °C

A mixture of (RS) 2-aminomethyl-piperidine-1-carboxylic acid tert butyl ester (1.28 g) and 2-chloropyrimidine was heated at 100° C. for 48 hours. After cooling to room temperature the mixture was column chromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant) to give the title compound (0.42 g) as an oil.

1. temperatureAfter cooling to room temperature the mixture
2. customchromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant)