Hexane → HCID 67426543, compound

Participants

Reaction Steps

A solution of (R)-4-(2-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one (8.0 g, 33.33 mmol) in N,N-dimethylformamide dimethylacetal (80 mL) was heated at 100° C. for 40 h. After the reaction mixture was cooled to room temperature, hexane (50 mL) was added. Product was collected by filtration and dried under high vacuum overnight to yield the title compound as yellow needles (6.95 g, 70% yield). 1H-NMR (DMSO-d6) δ 7.92 (dd, J=7.2 and 1.6 Hz, 1 H), 7.57 (s, 1 H), 7.42-7.34 (m, 2 H), 7.31-7.21 (m, 2 H), 7.09 (t, 1 H), 6.91-6.88 (m, 2 H), 4.48 (t, J=7.2 Hz, 1 H), 3.25-3.13 (m, 2 H), 3.02 (s, 6 H). LCMS m/e 296 [M+H].

Provenance & Evidence