HCID 67426900, compound → HCID 59489903, compound

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Reaction Steps

This product was prepared by using (R)-4-(3,4-dichlorophenyl)-2-((dimethylamino)methylene)-3,4-dihydronaphthalen-1(2H)-one and (R)-tert-butyl 3-guanidinopiperidine-1-carboxylate hydrochloride salt under the condition described in the general procedure 1 to afford the desired product in 57% yield as a light yellow solid. M.p.=85-87° C. 1H NMR 400 MHz (DMSO-d6) δ 8.29 (bs, 1 H), 8.12 (s, 1 H), 7.50-7.35 (m, 4 H), 7.08 (s, 1 H), 7.02-6.98 (m, 2 H), 4.39 (t, J=5.2 Hz, 1 H), 3.74 (bs, 2 H), 3.12-3.04 (m, 2 H), 2.90-2.84 (m, 2 H), 1.89-1.51 (m, 3 H), 1.38-1.24 (m, 11 H). LCMS m/e 525 (M+H).

Provenance & Evidence