Guanidine Hydrochloride → (R)-6-(2-fluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

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Reaction Steps

This was synthesized by using (R,E)-2-((dimethylamino)methylene)-4-(2-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one and guanidine hydrochloride as described in general procedure 1 to afford the desired product as hydrochloride salt. M.p.=154-155° C. 1H NMR 400 MHz (DMSO-d6) δ 8.26-8.24 (m, 1 H), 8.08 (s, 1 H), 7.46-7.39 (m, 2 H), 7.31-7.20 (m, 2 H), 7.05-7.00 (m, 2 H), 6.80-6.76 (m, 1 H), 6.51 (s, 2 H), 4.59 (t, J=6.8 Hz, 1 H), 3.11-3.2.96 (m, 2 H). LCMS m/e 292 (M+H).

Provenance & Evidence