Morpholine → HCID 59489700, compound

Participants

Reaction Steps

This product was synthesized as described in general procedure 2 except (R)-4-(6-(3,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate was used instead of 4-(6-(3-bromophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate and morpholine was used instead of piperidine to afford the title compound in 45% yield. M.p.=166-167° C. 1H NMR 400 MHz (CDCl3) δ 8.41 (dd, J=1.6 Hz, 7.6 Hz, 1H), 8.18 (s, 1H), 7.65-7.61 (m, 2H), 7.49-7.39 (m, 2H), 7.32 (d, J=8.4 Hz, 1H), 7.25-7.19 (m, 3H), 7.09 (s, 1H), 7.03-6.99 (m, 1H), 6.91 (dd, J=2.4 Hz, 8.4 Hz, 1H), 4.29-4.24 (m, 1H), 3.79-3.74 (m, 4H), 3.21 (dd, J=6.0 Hz, 15.6 Hz, 1H), 3.04 (dd, J=7.2 Hz, 15.6 Hz, 1H), 2.83-2.77 (m, 2H), 2.64-2.51 (m, 6H). LCMS m/e 531 (M+H).

Provenance & Evidence