N-Methylcyclohexylamine → HCID 67541172, compound

Participants

Reaction Steps

This product was synthesized as described in general procedure 2 except 4-(6-(4-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate was used instead of 4-(6-(3-bromophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate and N-methylcyclohexanamine was used instead of piperidine to afford 6-(4-chlorophenyl)-N-(4-(2-(cyclohexyl(methyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine hydrochloride. M.p.=157-163° C. 1H NMR 400 MHz (DMSO) δ 9.94 (bs, 1H), 9.61 (s, 1H), 8.34-8.29 (m, 2H), 7.81 (d, J=8.8 Hz, 2H), 7.54-7.45 (m, 2H), 7.35-7.31 (m, 2H), 7.26 (d, J=8.4 Hz, 2H), 7.16-7.09 (m, 3H), 4.44 (t, J=6.4 Hz, 1H), 3.40-3.07 (m, 4H), 3.02-2.95 (m, 2H), 2.75 (d, J=4.8 Hz, 3H), 2.08-1.98 (m, 2H), 1.84-1.78 (m, 2H), 1.63-1.06 (m, 7H). LCMS m/e 523 (M+H).

Provenance & Evidence