1-(2-Methoxyethyl)piperazine → HCID 67426012, compound

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Reaction Steps

This product was synthesized as described in general procedure 2 except 4-(6-(4-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate was used instead of 4-(6-(3-bromophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate and 1-(2-methoxyethyl)piperazine was used instead of piperidine to afford 6-(4-chlorophenyl)-N-(4-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine hydrochloride. M.p.=204-214° C. 1H NMR 400 MHz (DMSO) δ 12.03-11.35 (m, 2H), 9.64 (s, 1H), 8.34-8.29 (m, 2H), 7.82 (d, J=8.4 Hz, 2H), 7.54-7.46 (m, 2H), 7.35-7.31 (m, 2H), 7.25 (d, J=8.0 Hz, 2H), 7.16-7.10 (m, 3H), 4.47-4.41 (m, 1H), 3.90-3.30 (m, 16H), 3.30-3.00 (m, 5H). LCMS m/e 554 (M+H).

Provenance & Evidence