1-(2-Methoxyethyl)piperazine → HCID 59490024, compound

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Reaction Steps

This product was synthesized as described in general procedure 2 except 4-(6-(3,4-difluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate was used instead of 4-(6-(3-bromophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate and 1-(2-methoxyethyl)piperazine instead of piperidine to afford 6-(3,4-difluorophenyl)-N-(4-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine. M.p.=267-270° C. 1H NMR 400 MHz (DMSO-d6) δ 11.13 (s, 1H), 9.68 (s, 1H), 8.34 (s, 1H), 8.29 (d, J=6.8 Hz, 1H), 7.79 (d, J=8.0 Hz, 2H), 7.55-7.44 (m, 2H), 7.37-7.20 (m, 4H), 7.08 (d, J=5.2 Hz, 1H), 6.92-6.85 (br, 1H), 4.43 (t, J=6.4 Hz, 1H), 3.90-3.10 (m, 17H), 3.19-3.12 (m, 2H), 3.08-3.00 (m, 2H). LCMS m/e 557 (M+1).

Provenance & Evidence