1-(2-Methoxyethyl)piperazine → HCID 67427889, compound

Participants

Reaction Steps

This product was synthesized as described in general procedure 2 except 4-(6-(2-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate was used instead of 4-(6-(3-bromophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate and 1-(2-methoxyethyl)piperazine was used instead of piperidine to afford 6-(2-chlorophenyl)-N-(4-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine hydrochloride. 1H-NMR 400 MHz (CDCl3) δ 8.43 (d, J=7.4, 1H), 8.11 (s, 1H), 7.63 (d, J=7.4 Hz, 2H), 7.44-7.39 (m, 3H), 7.40 (s, 1H), 7.21 (d, J=6.6 Hz, 2H), 7.15-7.12 (m, 1H), 7.02 (d, J=7.8, 2H), 6.73 (d, J=6.2, 1H), 4.85 (m, 1H), 3.35 (s, 3H), 3.55 (t, J=5.4, 2H), 3.18-3.13 (m, 3H), 2.66-2.61 (m, 11H). LCMS m/e 554 (M+H).

Provenance & Evidence