1-(2-Methoxyethyl)piperazine → HCID 59489611, compound

Participants

Reaction Steps

This was synthesized by using 4-(6-(2-(trifluoromethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 1-(2-methoxyethyl)piperazine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=139-140° C. 1H NMR 400 MHz (DMSO-d6) δ 9.55 (s, 1 H); 8.38-8.34 (m, 2 H), 7.82-7.75 (m, 3 H), 7.56 (t, 1 H), 7.49-7.40 (m, 3 H), 7.27 (d, J=8.0 Hz, 1 H), 7.18-7.15 (m, 2 H), 6.76 (d, J=7.2 Hz, 1 H), 4.64 (t, J=7.6 Hz, 1 H), 3.43-3.37 (m, 2 H), 3.34 (s, 3 H), 3.21-3.11 (m, 2 H), 2.69-2.65 (m, 2 H), 2.50-2.43 (m, 12). LCMS 588 (M+H).

Provenance & Evidence