1-Methylpiperazine → HCID 59489835, compound

Participants

Reaction Steps

This was synthesized by using 4-(6-(2-(trifluoromethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, N-Methylpiperazine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=157-158° C. 1H NMR 400 MHz (DMSO-d6) δ 9.55 (s, 1 H); 8.38-8.34 (m, 2 H), 7.82-7.49 (m, 3 H), 7.58 (t, 1 H), 7.51-7.40 (m, 3 H), 7.27 (d, J=8.4 Hz, 1 H), 7.18-7.15 (m, 2 H), 6.77 (d, J=7.6 Hz, 1 H), 4.64 (t, J=7.6 Hz, 1 H), 3.35 (bs, 2 H), 3.17-3.08 (m, 3 H), 2.69-2.65 (m, 2 H), 2.50-2.31 (m, 7 H), 2.15 (s, 3 H). LCMS 544 (M+H).

Provenance & Evidence