tert-Butyl piperazine-1-carboxylate → HCID 59489847, compound

Participants

Reaction Steps

This was synthesized by using 4-(6-(2-(trifluoromethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, N-boc-piperazine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=234-235° C. 1H NMR 400 MHz (DMSO-d6) δ 8.44 (d, J=7.6 Hz, 1 H), 8.18 (s, 1 H), 7.72 (d, J=7.6 Hz, 1 H), 7.66 (d, J=8.0 Hz, 1 H), 7.46-7.34 (m, 3 H), 7.27-7.21 (m, 3 H), 7.15-7.13 (m, 2 H), 6.90 (d, J=7.6 Hz, 1 H), 4.81 (t, J=7.2 Hz, 1 H), 3.49-3.47 (m, 4 H), 3.23-3.18 (m, 1 H), 3.07-3.01 (m, 1 H), 2.83-2.79 (m, 2 H), 2.65-2.61 (m, 2 H), 1.48 (s, 9 H). LCMS 630 (M+H).

Provenance & Evidence