HCID 43252569, compound → HCID 67426973, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(2-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 2-(4-(2-methoxyethyl)piperazin-1-yl)ethanamine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=143-145° C. 1H NMR (DMSO) 400 MHz δ 9.67 (s, 1H), 8.36-8.32 (m, 1H), 8.30 (s, 1H), 7.82-7.78 (m, 2H), 7.54-7.43 (m, 3H), 7.27-7.22 (m, 3H), 7.18-7.13 (m, 1H), 7.00 (d, J=7.6 Hz, 1H), 6.79-6.75 (m, 1H), 4.78 (t, J=6.0 Hz, 1H), 3.86-3.70 (m, 5H), 3.69-3.24 (m, 12H), 3.22-3.09 (m, 2H), 3.07-2.98 (m, 2H). LCMS 554 [M+H]. Calc. for C33H36ClON5.3.07 Hydrochloric acid.0.34 Ethyl Acetate.0.04 Water: C, 59.23; H, 6.06; N, 10.05. Found C, 59.17; H, 6.05; N, 10.05.

Provenance & Evidence