Piperidine → HCID 67541199, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(2-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, piperidine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=164-167° C. 1H NMR (DMSO) 400 MHz δ 10.10 (bs, 1H), 9.64 (s, 1H), 8.36-8.32 (m, 1H), 8.30 (s, 1H), 7.80 (d, J=8.4 Hz, 2H), 7.53-7.43 (m, 3H), 7.26-7.20 (m, 3H), 7.18-7.13 (m, 1H), 7.00 (d, J=7.2 Hz, 1H), 6.79-6.75 (m, 1H), 4.77 (t, J=6.8 Hz, 1H), 3.51-3.46 (m, 2H), 3.25-3.09 (m, 4H), 3.01-2.96 (m, 2H), 2.93-2.83 (m, 2H), 1.80-1.67 (m, 5H), 1.41-1.31 (m, 1H). LCMS 495 [M+H]. Calc. for C31H31ClN4.2.07 Hydrochloric acid.0.08 Ethyl Acetate: C, 65.13; H, 5.88; N, 9.70. Found C, 65.13; H, 5.84; N, 9.69.

Provenance & Evidence