HCID 43252569, compound → HCID 67450804, compound

Participants

Reaction Steps

This was synthesized by using 4-(6-(2,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 2-(4-(2-methoxyethyl)piperazin-1-yl)ethanamine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=208-212° C. 1H NMR (DMSO) 400 MHz δ 9.70 (s, 1H), 8.39-8.31 (m, 2H), 7.85-7.80 (m, 2H), 7.71-7.69 (m, 1H), 7.58-7.46 (m, 2H), 7.31-7.25 (m, 3H), 7.05 (d, J=7.6 Hz, 1H), 6.76 (d, J=8.4 Hz, 1H), 4.80-4.75 (m, 1H), 3.88-3.00 (m, 21H). LCMS 588 [M+H]. Calc. for C33H35Cl2N5O.3.1 Hydrochloric Acid.0.3 Water 0.2 Ethyl Acetate: C, 56.03; H, 5.61; N, 9.67. Found C, 56.04; H, 5.60; N, 9.66.

Provenance & Evidence