Piperidine → HCID 67426579, compound

Participants

Reaction Steps

This was synthesized by using 4-(6-(2,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, piperidine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=225-230° C. 1H NMR (DMSO) 400 MHz δ 10.05 (bs, 1H), 9.66 (s, 1H), 8.36 (d, J=6.4 Hz, 1H), 8.32 (s, 1H), 7.83-7.80 (m, 2H), 7.72-7.70 (m, 1H), 7.57-7.46 (m, 2H), 7.30-7.22 (m, 3H), 7.05 (d, J=7.6 Hz, 1H), 6.76 (d, J=8.0 Hz, 1H), 4.80-4.75 (m, 1H), 3.53-3.48 (m, 2H), 3.27-3.07 (m, 4H), 3.03-2.86 (m, 4H), 1.86-1.69 (m, 5H), 1.42-1.38 (m, 1H). LCMS 529 [M+H]. Calc. for C31H30Cl2N4.2.1 Hydrochloric acid: C, 61.44; H, 5.34; N, 9.24. Found C, 61.45; H, 5.32; N, 9.31.

Provenance & Evidence