N-Methylbutylamine → HCID 59490189, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(4-fluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, N-methylbutan-1-amine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=164-166° C. 1H NMR (DMSO-d6) 400 MHz δ 10.65 (brs, 1H), 9.78 (s, 1H), 8.32-8.35 (m, 2H), 7.79 (d, J=8.6 Hz, 2H), 7.51 (t, J=5.0 Hz, 2H), 7.26 (d, J=8.6 Hz, 2H), 7.02-7.08 (m, 5H), 4.46 (t, J=6.2 Hz, 1H), 3.13-3.18 (m, 5H), 2.99-3.03 (m, 3H), 2.79 (d, J=5.0 Hz, 3H), 1.17 (t, J=7.8 Hz, 2H), 1.31 (m, 2H), 1.27-1.32 (m, 3H), 0.91 (t, J=7.4 Hz, 3H) LCMS m/e 481 [M+H].

Provenance & Evidence