Piperidine → HCID 59489914, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(4-fluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, piperidine and triethylamine as described in general procedure 2 to afford the desired product. M.p.=185-188° C. 1H NMR (CDCl3) 400 MHz δ 12.19 (brs, 1H), 10.89 (brs, 1H), 8.36 (brs, 1H), 8.01 (brs, 1H), 7.69 (d, J=6.6 Hz, 2H), 7.58-7.59 (m, 2H), 7.35 (d, J=6.2 Hz, 2H), 7.26 (d, J=2.7 Hz, 1H, 7.11-7.12 (m, 1H), 7.01-7.11 (m, 3H), 4.14 (s, 1H), 3.63 (d, J=10.5 Hz), 3.31-3.33 (m, 3H), 3.12-3.17 (m, 3H), 2.74 (d, J=11.2 Hz, 2H), 2.36 (d, J=12.1 Hz, 2H), 2.09 (s, 1H), 1.92-1.95 (m, 3H), 1.43-1.46 (m, 1H). LCMS m/e 479 [M+H].

Provenance & Evidence