Piperidine → HCID 67542225, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(4-chlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, piperidine and triethylamine as described in general procedure 2 to give a yellow solid. M.p.=261-263° C. 1H NMR 400 MHz (DMSO-d6) δ 9.72 (s, br, 1H), 9.59 (s, 1H), 8.32-8.28 (m, 2H), 7.79 (d, J=8.4 Hz, 2H), 7.50-7.44 (m, 2H), 7.31 (dd, J=1.8, 4.8 Hz, 2H), 7.21 (d, J=8.4 Hz, 2H), 7.11-7.08 (m, 3H), 4.42 (t, J=6.2 Hz, 1H), 3.49 (d, J=11.2 Hz, 2H), 3.32-2.84 (m, 8H), 1.79-1.68 (m, 5H), 1.38 (m, 1H). LCMS m/e 495 (M+H).

Provenance & Evidence