1-(2-Methoxyethyl)piperazine → HCID 67541146, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(3,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 1-(2-methoxyethyl)piperazine and triethylamine as described in general procedure 2 to give a yellow solid. M.p.=248-250° C. 1H NMR 400 MHz (DMSO-d6) δ 9.63 (s, br, 1H) 8.33-8.29 (m, 2H), 7.79 (d, J=8.0 Hz, 2H), 7.52-7.42 (m, 2H), 7.23 (d, J=8.8 Hz, 2H), 7.10 (m, 2H), 7.03-7.00 (dd, J=2.0, 8.4 Hz, 2H), 4.46 (t, J=6.4 Hz, 1H), 3.78-3.36 (m, 17H), 3.15 (t, J=6.0 Hz, 2H), 3.01 (m, 2H). LCMS m/e 588 (M+H).

Provenance & Evidence