Triethylamine → HCID 59490214, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(2-fluorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 1-(2-methoxyethyl)piperazine and triethylamine as described in general procedure 6 to afford the desired product as hydrochloride salt. M.p.=148-150° C. 1H NMR 400 MHz (CDCl3) δ 8.42 (d, J=7.6 Hz, 1 H), 8.15 (s, 1 H), 7.59-7.54 (m, 2 H), 7.46-7.37 (m, 2 H), 7.29-7.25 (m, 1 H), 7.19-7.13 (m, 2 H), 7.09-7.04 (m, 2 ), 6.94-6.87 (m, 2 H), 6.75 (t, J=7.6 Hz, 1 H), 4.67 (t, J=6.4 Hz, 1 H), 3.52 (t, J=5.2 Hz, 2 H), 3.35 (s, 2 H), 3.21-3.08 (m, 2 H), 2.86-2.82 (m, 2 H), 2.69-2.58 (m, 13 H). LCMS m/e 538 (M+H).

Provenance & Evidence