HCID 43252569, compound → HCID 67427141, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(3,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, 2-(4-(2-methoxyethyl)piperazin-1-yl)ethanamine and triethylamine as described in general procedure 6 to afford the desired product as hydrochloride salt. M.p.=220-225° C. 1H NMR (DMSO) 400 MHz δ 12.25 (bs, 1H), 11.70 (bs, 1H), 9.67 (s, 1H), 8.34-8.30 (m, 2H), 7.79 (s, 1H), 7.67 (d, J=9.6 Hz, 1H), 7.58 (t, J=7.6 Hz, 1H), 7.52-7.41 (m, 3H), 7.28 (t, J=8.0 Hz, 1H), 7.10 (d, J=7.6 Hz, 1H), 7.03-6.99 (m, 1H), 6.89 (d, J=8.0 Hz, 1H), 4.46 (t, J=6.4 Hz, 1H), 3.90-3.68 (m, 6H), 3.68-3.32 (m, 8H), 3.28 (s, 3H), 3.18-3.12 (m, 2H), 3.11-3.05 (m, 2H). LCMS: 588 m/e [M+H]. Calc. for C33H35Cl2N5.2.60 Hydrochloric acid.1.42 Water.0.03 Ethyl Acetate: C, 55.90; H, 5.76; N, 9.84. Found C, 55.91; H, 5.76; N, 9.84.

Provenance & Evidence