N-Methylbutylamine → HCID 67541190, compound

Participants

Reaction Steps

This was synthesized by using (S)-4-(6-(3,4-dichlorophenyl)-5,6-dihydrobenzo[h]quinazolin-2-ylamino)phenethyl methanesulfonate, N-methylbutan-1-amine and triethylamine as described in general procedure 6 to afford the desired product as hydrochloride salt. M.p.=162-166° C. 1H NMR (DMSO) 400 MHz δ 10.24 (bs, 1H), 9.63 (s, 1H), 8.34-8.29 (m, 2H), 7.79 (bs, 1H), 7.68-7.65 (m, 1H), 7.56-7.45 (m, 3H), 7.43-7.41 (m, 1H), 7.27 (t, J=8.0 Hz, 1H), 7.11 (d, J=7.6 Hz, 1H), 7.04-7.00 (m, 1H), 6.87 (d, J=8 Hz, 1H), 4.46 (t, J=6.4 Hz, 1H), 3.34-3.10 (m, 5H), 3.06-2.96 (m, 3H), 2.79 (t, J=4.8 Hz, 3H) 1.68-1.59 (m, 2H), 1.32-1.24 (m, 2H), 0.87 (t, J=7.6 Hz, 3H). LCMS m/e 531 [M+H]. Calc. for C31H32Cl2N4.1.93 Hydrochloric acid.0.30 Water.0.17 Ethyl Acetate: C, 61.15; H, 5.81; N, 9.00. Found C, 61.15; H, 5.82; N, 9.00.

Provenance & Evidence