HCID 67426541, compound → HCID 59489602, compound

HRID 1808082Notes

Reaction equation

HRID 1808082 reaction equation
CN(/[CH:4]=[C:5]1\[C:6](=O)[C:7]2[C:12]([C@H:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[CH2:14]\1)=[CH:11][CH:10]=[CH:9][CH:8]=2)C.[NH:23]([C:27]1[CH:32]=[CH:31][C:30]([N:33]2[CH2:38][CH2:37][N:36]([C:39]([O:41][CH2:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)=[O:40])[CH2:35][CH2:34]2)=[CH:29][CH:28]=1)[C:24]([NH2:26])=[NH:25]>>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C@H:13]1[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]2[N:26]=[C:24]([NH:23][C:27]3[CH:32]=[CH:31][C:30]([N:33]4[CH2:34][CH2:35][N:36]([C:39]([O:41][CH2:42][C:43]5[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=5)=[O:40])[CH2:37][CH2:38]4)=[CH:29][CH:28]=3)[N:25]=[CH:4][C:5]=2[CH2:14]1

Participants

3

Reactant 2

HCID 67426541HCID 67426541, compoundHCID 178512566HCID 178512566, compound

Product 1

HCID 59489602HCID 59489602, compound

Procedure

This was synthesized by using (R,Z)-2-((dimethylamino)methylene)-4-(2-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one and benzyl 4-(4-guanidinophenyl)piperazine-1-carboxylate as described in general procedure 1. LCMS m/e 586 (M+H).

Workup

  1. customThis was synthesized

Sources & evidence

ORD record
ord-ac2e55852783440089bf1725643dce6c
Source dataset
uspto-grants-2013_01
Patent number
US08357694B2

Reaction notes

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