HCID 67426541, compound → HCID 59490161, compound

HRID 1808084Notes

Reaction equation

HRID 1808084 reaction equation
CN(/[CH:4]=[C:5]1\[C:6](=O)[C:7]2[C:12]([C@H:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[F:21])[CH2:14]\1)=[CH:11][CH:10]=[CH:9][CH:8]=2)C.[OH:23][CH2:24][CH2:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:39]=[CH:38][C:37]([NH:40][C:41]([NH2:43])=[NH:42])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C@H:13]1[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]2[N:43]=[C:41]([NH:40][C:37]3[CH:38]=[CH:39][C:34]([N:31]4[CH2:30][CH2:29][N:28]([CH2:27][CH2:26][CH2:25][CH2:24][OH:23])[CH2:33][CH2:32]4)=[CH:35][CH:36]=3)[N:42]=[CH:4][C:5]=2[CH2:14]1

Participants

3

Reactant 2

HCID 67426541HCID 67426541, compoundHCID 178512565HCID 178512565, compound

Product 1

HCID 59490161HCID 59490161, compound

Procedure

This was synthesized by using (R,Z)-2-((dimethylamino)methylene)-4-(2-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one and 1-(4-(4-(4-hydroxybutyl)piperazin-1-yl)phenyl)guanidine as described in general procedure 1. LCMS m/e 524 (M+H).

Workup

  1. customThis was synthesized

Sources & evidence

ORD record
ord-df954b136259476ab47d3448e2fb91d7
Source dataset
uspto-grants-2013_01
Patent number
US08357694B2

Reaction notes

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