HCID 86634822, compound → HCID 68785405, compound

Participants

Reaction Steps

A solution of (S)-benzyl 2-(1H-indol-3-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl-carbamate (1.41 g, 3.73 mmol) in anhydrous tetrahydrofuran (100 mL) was mixed with 10% palladium on activated carbon (160 mg) and hydrogenated for 24 h at room temperature and at 3 bar. A further portion of 20% palladium on activated carbon (160 mg) was added and the mixture hydrogenated for a further 24 h at 3 bar and 40° C. The catalyst was then filtered off, the filtrate concentrated to low volume in a vacuum and the residue (1.24 g) purified by flash chromatography (100 g, 20×4.0 cm) with chloroform/methanol (95:5).

Provenance & Evidence