Chloroacetone → HCID 68918267, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (R)-tert-butyl-1-amino-3-(1H-Indol-3-yl)-1-thioxopropan-2-yl carbamate (6.49 g, 20.3 mmol) in anhydrous dimethoxyethane (100 mL) was mixed with powdered potassium hydrogencarbonate (10.1 g, 101 mmol) and chloroacetone (9.69 g, 8.4 mL, 101 mmol) and stirred for 8 h at 70° C. and over the weekend at 45° C. The reaction mixture was then filtered and the filtrate concentrated to low volume in a vacuum.

Provenance & Evidence