Sodium Sulfate → HCID 68920855, compound

Participants

Reaction Steps

A solution of tert-butyl-(1R)-1-(4-hydroxy-4-methyl-4,5-dihydrothiazol-2-yl)-2-(1H-indol-3-yl)ethyl carbamate (7.12 g, 18.9 mmol) in toluol (150 mL) was mixed with sodium sulphate (9.00 g) and stirred for 1 h with reflux. The mixture was filtered, the filtrate concentrated to low volume in a vacuum and the residue purified by flash chromatography (400 g, 20×7.5 cm) with ethyl acetate/cyclohexane (1:2).

Provenance & Evidence