Hydrochloric Acid → HCID 178482562, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(2-(1H-Indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl)-N-(4-dimethylamino-4-phenylcyclohexyl)-2,2,2-trifluoroacetamide (non-polar diastereomer) (200 mg, 0.38 mmol) in methanol (10 mL) was mixed with 37% hydrochloric acid (10 mL) and stirred for 7 h at 100° C. in a Teflon pressure vessel. Methanol (10 mL) and 37% hydrochloric acid (10 mL) was then added again and the mixture stirred a further 6 h at 100° C. The reaction solution was then concentrated to low volume in a vacuum and the residue (250 mg) purified by flash chromatography (37 g, 20×2.1 cm) with dichloromethane/methanol [8:2+1% NH3 (32% in H2O)].

Provenance & Evidence