Hydrochloric Acid → HCID 178482562, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(2-(1H-indol-3-yl)-1-(1H-tetrazol-5-yl)ethyl)-N-(4-dimethylamino-4-phenylcyclohexyl)-2,2,2-trifluoroacetamide (100 mg, 0.19 mmol) in methanol (10 mL) was mixed with 37% hydrochloric acid (3 mL) and stirred for 7 h at 100° C. in a Teflon pressure vessel. 37% hydrochloric acid (3 mL) was then added again, the mixture stirred for a further 24 h at 100° C. and then concentrated to low volume in a vacuum. The raw product was purified by flash chromatography (85 g, 20×3.6 cm) with dichloromethane/methanol [2:1+1% NH3 (32% in H2O)].

Provenance & Evidence