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3-Fluoro-4-(trifluoromethoxy)benzylamine → N-[3-fluoro-4-(trifluoromethoxy)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluoro-4-(trifluoromethoxy)benzylamine | HCID 17750674 | — |
| 反応物 | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid | HCID 57732214 | — |
| 生成物 | N-[3-fluoro-4-(trifluoromethoxy)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide | HCID 57732217 | — |
反応手順
The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 3-fluoro-4-(trifluoromethoxy)benzylamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08357711B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-698c2660e809466c887e6555b924a85c |
| 出典メモ | uspto-grants-2013_01 |