HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Trifluoromethylphenyl)Ethylamine → 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Trifluoromethylphenyl)Ethylamine | HCID 2782449 | — |
| Reactant | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid | HCID 57732214 | — |
| Product | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide | HCID 57732003 | — |
Reaction Steps
The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 1-[4-(trifluoromethyl)phenyl]ethanamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08357711B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0075686f056c48449cedd30c761b73c3 |
| Source note | uspto-grants-2013_01 |