HCID 86660752, compound → HCID 24988150, compound

Participants

Reaction Steps

2,2,5,8-Tetramethyl-4,10-dioxo-3,6,9-trioxa-5-azatridecan-13-oic acid (227 mg, 0.744 mmol) was dissolved in 4 mL TFA. The reaction mixture was stirred at room temperature for 4 h and concentrated. The crude product was purified by silica gel flash column chromatography using 12% MeOH/dichloromethane as eluent. The desired product was obtained as a colorless gel (30 mg, 0.146 mmol, 20%). 1H NMR (CD3OD, 300 MHz): δ (ppm) 1.17 (d, 3 H, J=6.6 Hz), 2.58 (s, 3 H), 2.61 (s, 3 H), 3.66 (d, 2 H, J=5.4 Hz), 5.10-5.16 (m, 1 H).

Provenance & Evidence