反应详情

In accordance with the third aspect of the present invention, a process of producing docetaxel trihydrate is provided. The process comprises a) combining anhydrous docetaxel, and acetonitrile; b) heating the mixture of step a) to about 30-60° C.; c) adding water to the mixture of the heated mixture of step d); cooling the mixture of c) to about 10-30° C. to obtain a slurry; and e) filtering, washing, and drying the slurry of step d) to obtain docetaxel trihydrate.

1. temperaturecooling
2. additionthe mixture of c) to about 10-30° C.
3. customto obtain a slurry
4. filtrationand e) filtering
5. washwashing
6. customdrying the slurry of step d)