Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Docetaxel | HCID 148124 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | C43H53NO14.3H2O | HCID 24721032 | 328.1% |
Reaction Steps
Docetaxel anhydrous (about 0.8 Kg), acetonitrile (about 3.8 Kg) and glacial acetic acid (about 7.6 g) are charged into a suitable vessel. The mixture is heated to NMT 45° C., and purified process water (about 9.6 Kg) is added for precipitation. The slurry is filtered, washed and dried under a moist environment to provide docetaxel trihydrate (about 0.7 Kg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08357811B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-1025116010774142916e38c41eac944c |
|---|
| Source note | uspto-grants-2013_01 |
|---|
