Methanol → Methyl 3-hydroxy-4-iodobenzoate

HRID 1808298Notes

Reaction equation

[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[OH:11].S(=O)(=O)(O)O.[CH3:17]O>>[OH:11][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[I:1])[C:6]([O:8][CH3:17])=[O:7]

Participants

Reactant 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 7368543-Hydroxy-4-iodobenzoic acid

Product 1

HCID 10378812Methyl 3-hydroxy-4-iodobenzoate

Procedure

4-Iodo-3-hydroxybenzoic acid (VI) is esterified with methanol in the presence of sulphuric acid in order to provide methyl 3-hydroxy-4-iodobenzoate (VII).

Sources & evidence

ORD record: ord-f38496897c0140369b4a3b5798e342ea
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08357819B2

Reaction notes

Loading…