Ammonia → Cyclohexanecarboxamide, 3-amino-4-hydroxy-N,N-dimethyl-, (1S,3R,4R)-

Temperature

40 °C

A 28% aqueous ammonia solution (5 ml) was added to (1S,3S,6R)-N,N-dimethyl-7-oxabicyclo[4.1.0]heptane-3-carboxamide (1 g) at room temperature. After stirring at 40° C. for 5 hours, the solvent was concentrated under reduced pressure to obtain a crude form of (1S,3R,4R)-3-amino-4-hydroxy-N,N-dimethylcyclohexanecarboxamide (1.18 g). The obtained crude form was dissolved in water (5 ml). To the solution, di-tert-butyl dicarbonate (1.93 g) and a 10 N aqueous sodium hydroxide solution (1.5 ml) were then added at room temperature. After stirring at 40° C. for 2 hours, the mixture was subjected to extraction with 4-methyl-2-pentanone (MIBK) (5 ml) three times, and the extraction solvent was distilled off under reduced pressure. To the residue, 4-methyl-2-pentanone (MIBK) (3 ml) was added, and the mixture was stirred at room temperature. The precipitated crystals were collected by filtration and then dried to obtain the title compound (1.26 g).

1. concentrationthe solvent was concentrated under reduced pressure

ORD record

ord-d1873d5b362f44ca88f52ed2d9e483d1

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08357808B2