Methanesulfonyl chloride → HCID 86645317, compound

Participants

Reaction Steps

MsCl (3.32 mmol, 1.5 equiv.) was added at 0° C. to a solution of (2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)methanol (2.22 mmol, 1 equiv.) and TEA (2.5 equiv.) in DCM (16 ml), and the mixture was stirred for 1 h. The reaction mixture was diluted with DCM, extracted with sat. sodium hydrogen carbonate solution, water and sat. NaCl solution and dried over Na2SO4. The solvent was removed in vacuo and the crude product was purified by column chromatography (silica gel).

Provenance & Evidence