Trifluoroacetic acid → HCID 86645318, compound

Participants

Reaction Steps

tert-Butyl 3-(pyridin-4-yl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate (0.48 g, 1.5 mmol) was dissolved in dichloromethane (10 ml) and cooled, and trifluoroacetic acid (1.2 ml, 15 mmol) was added slowly thereto. After refluxing for 2 h, the solvent was removed in vacuo and the residue was co-evaporated with 30 ml of each of toluene and methanol. Yield: 0.74 g (100%)

Provenance & Evidence