HRID1808364

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

HCID34178604

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

C13H24N2O2

结构：COc1cc(C)c(S(=O)(=O)N2CCCc3ccc(CC(=O)O)cc32)c(C)c1

HCID59483794

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C)c(S(=O)(=O)N2CCCc3ccc(CC(=O)N4CCC5(CC4)CCN(C(=O)OC(C)(C)C)C5)cc32)c(C)c1

HCID59483808

未命名化合物

收率 53%

PROCEDURE

实验过程

The target compound was prepared according to general working procedure GWP X (TBTU coupling) from the starting materials 2-(1-(4-methoxy-2,6-dimethylphenyl-sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)acetic acid (E-10) and tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (F-26). Yield: 53%

WORKUP

后处理

customThe target compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a2b094200563440b898bb05401ba1fbf
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08357717B2
来源说明: uspto-grants-2013_01

反应 SMILES

CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:23][O:24][C:25]1[CH:30]=[C:29]([CH3:31])[C:28]([S:32]([N:35]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([CH2:45][C:46](O)=[O:47])[CH:43]=3)[CH2:38][CH2:37][CH2:36]2)(=[O:34])=[O:33])=[C:27]([CH3:49])[CH:26]=1.[CH2:50]1[C:54]2([CH2:59][CH2:58][NH:57][CH2:56][CH2:55]2)[CH2:53][CH2:52][N:51]1[C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61]>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH3:49])[C:28]([S:32]([N:35]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([CH2:45][C:46]([N:57]4[CH2:56][CH2:55][C:54]5([CH2:50][N:51]([C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61])[CH2:52][CH2:53]5)[CH2:59][CH2:58]4)=[O:47])[CH:43]=3)[CH2:38][CH2:37][CH2:36]2)(=[O:33])=[O:34])=[C:29]([CH3:31])[CH:30]=1