O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 59483808, compound

HRID 1808364Notes

Reaction equation

HRID 1808364 reaction equation
CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:23][O:24][C:25]1[CH:30]=[C:29]([CH3:31])[C:28]([S:32]([N:35]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([CH2:45][C:46](O)=[O:47])[CH:43]=3)[CH2:38][CH2:37][CH2:36]2)(=[O:34])=[O:33])=[C:27]([CH3:49])[CH:26]=1.[CH2:50]1[C:54]2([CH2:59][CH2:58][NH:57][CH2:56][CH2:55]2)[CH2:53][CH2:52][N:51]1[C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61]>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH3:49])[C:28]([S:32]([N:35]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([CH2:45][C:46]([N:57]4[CH2:56][CH2:55][C:54]5([CH2:50][N:51]([C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61])[CH2:52][CH2:53]5)[CH2:59][CH2:58]4)=[O:47])[CH:43]=3)[CH2:38][CH2:37][CH2:36]2)(=[O:33])=[O:34])=[C:29]([CH3:31])[CH:30]=1

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 34178604tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylateHCID 594837942-(1-(4-Methoxy-2,6-dimethylphenyl-sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)acetic acid

Product 1

HCID 59483808HCID 59483808, compoundYield 53%

Procedure

The target compound was prepared according to general working procedure GWP X (TBTU coupling) from the starting materials 2-(1-(4-methoxy-2,6-dimethylphenyl-sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)acetic acid (E-10) and tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (F-26). Yield: 53%

Workup

  1. customThe target compound was prepared

Sources & evidence

ORD record
ord-a2b094200563440b898bb05401ba1fbf
Source dataset
uspto-grants-2013_01
Patent number
US08357717B2

Reaction notes

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