Potassium Cyanide → HCID 59483859, compound

Participants

Reaction Steps

Potassium cyanide (0.133 g, 0.0020 mol) was added to a solution of 6-(bromomethyl)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)indoline (0.7 g, 0.0017 mol) in methanol (14 ml) and water (2 ml), and the resulting reaction mixture was refluxed for 4 h. The mixture was then diluted with ethyl acetate (400 ml) and washed with saturated sodium chloride solution (2×), water (2×), saturated iron sulfate solution and finally with saturated sodium chloride solution. It was then dried (Na2SO4), filtered and concentrated in vacuo. The resulting crude product was used directly in the following stage. Yield: 0.6 g (99%).

Provenance & Evidence