Diisopropylethylamine → HCID 59483838, compound

Participants

Reaction Steps

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid (2 g, 0.0072 mol), 0-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (2.3 g, 0.0072 mol) and 1-hydroxybenzotriazole hydrate (0.99 g, 0.0072 mol) were dissolved in tetrahydrofuran, under nitrogen, and the mixture was stirred for 30 min at RT. A solution of 3-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecane dihydrochloride (F-09) (2.18 g, 0.0072 mol) and diisopropylethylamine (DIPEA) (4.28 g, 0.025 mol) in tetrahydrofuran was added, and the reaction mixture was stirred for 15 h at RT. Tetrahydrofuran was then removed in vacuo, the residue was taken up in ethyl acetate and sat. sodium hydrogen carbonate solution, and the phases were separated. The aqueous phase was extracted with ethyl acetate, and the combined organic phases were in turn washed with sat. sodium chloride solution, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate/methanol 20:1+1% 25% ammonia solution (aq.)). Yield: 1.91 g (54%).

Provenance & Evidence