Phthalic Anhydride → HCID 58054415, compound

Participants

Role	Name	HCID	Charge
Reactant	Phthalic Anhydride	HCID 6811	—
Reactant	4-Methoxy-1H-indazol-3-amine	HCID 18526053	—
Reactant	1,1-dimethylethyl 3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazole-1-carboxylate	HCID 58054456	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 58054415	HCID 58054415	81%

Reaction Conditions

Temperature	110 °C

Reaction Steps

4-(Methyloxy)-1H-indazol-3-amine (for a preparation see Intermediate 1) (500 mg, 3 mmol) and phthalic anhydride (680 mg, 4.6 mmol) (available from Aldrich) were dissolved in 1,4-dioxane (5 mL) at room temperature. The reaction mixture was stirred at 110° C. overnight, and then it was cooled and concentrated under reduced pressure. The residue was triturated and sonicated with 50 mL of ether. The solid was collected by filtration and dried in a vacuum oven to obtain a brown solid (711 mg, 81%). LCMS (System B) RT=2.82 min, ES+ve m/z 294 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08357716B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-99ee58fa12da4e3ea9ffabf1f8dd8127
Source note	uspto-grants-2013_01